Background

Lack of persistent weight loss may limit current intragastric balloon therapy. Static balloons, those that do not change in volume appear to be associated with accommodation with plateauing of weight loss in large mammals. Here we report a novel endoscopically administered gastric resident device that supports dynamic satiety induction to approximate the natural satiety induction process associated with episodic meal ingestion. The device expands pre-prandially and occupies the gastric cavity, then shrinks to a minimal volume after the meal. We have developed two gastric residency and dynamic expansion mechanisms based on robotic and balloon approaches. The system is programmed to stimulate satiety autonomously over the course of treatment without manual assistance. We have conducted preliminary evaluation in vitro and in vivo in the swine model. This system enables a minimally-invasive dynamic satiety induction to support weight loss.